Next-Generation IEDB Tools Website and API - Release 2.0

Release 2.0 of the Next-Generation IEDB Tools Website is now live! This release includes three new applications developed to support the Cancer Epitope Database and Analysis Resource (CEDAR).

Head over to https://nextgen-tools.iedb.org/ to try it out!

Release notes - 2.0 (Jun 28, 2024)

  • New Tools!
    • Peptide Expression Annotator (PepX). With a list of human peptides and a selected expression dataset, this tool will estimate the abundance of each of the peptides in the list based on the expression levels of the genes/transcripts in which they are contained.
    • Peptide Variant Comparison. This tool enables class I binding/elution/immunogenicity predictions of peptide pairs. The tool was developed with the intended use of comparing neoepitopes to germ line peptides, but it can be used to compare any two peptides.
    • Mutated Peptide Generator. Given a paired tumor/normal VCF file, this tool will determine the novel peptides (neoepitopes) that can be generated.